Children's Hospital and Health System is the region's only independent health care system dedicated solely to the health and well-being of children. Children's Hospital of Wisconsin, the health system's flagship member, is recognized as one of the leading pediatric health care centers in the United States. The hospital is included on Child magazine's 10 Best Children's Hospitals list. Other health system entities include Children's Hospital of Wisconsin-Fox Valley, Children's Hospital of Wisconsin-Kenosha, Children's Hospital and Health System Foundation, Children's Health Education Center, Children's Medical Group, Children's Physician Group, Children's Specialty Group, Surgicenter of Greater Milwaukee, Children's Service Society of Wisconsin, Children's Research Institute, Children's Community Health Plan, Seeger Health Resources and National Outcomes Center.

Children's Hospital and Health System serves children throughout Wisconsin, Michigan's Upper Peninsula, northern Illinois and beyond through medical care, advocacy, education and pediatric medical research.